HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → 1-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 5-Fluoro-2,3-dihydro-1-benzofuran-2-carboxylic acid | HCID 13102403 | — |
| Product | 1-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine | HCID 21472261 | — |
Reaction Steps
0.03 mol of 1-[(5-fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine (resulting from the condensation of 5-fluoro-2,3-dihydrobenzofuran-2-carboxylic acid with N-benzylpiperazine) is dissolved in 150 ml of anhydrous tetrahydrofuran (T.H.F.). Two times 0.03 mol of lithium aluminum hydride are added in the form of pellets. The mixture is stirred at room temperature. The title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05691340 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-1154c08401d94ffdb6bd97a2d2570282 |
| Source note | uspto-grants-1997_11 |