HCID 22100389, compound → HCID 21472345, compound

HRID 2294892Notes

Reaction equation

HRID 2294892 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[NH:12][C:11]([CH2:13][CH2:14][CH2:15][CH3:16])=[N:10][C:5]2=[N:6][C:7]=1[CH2:8][OH:9]>C(Cl)Cl.O=[Mn]=O>[Br:1][C:2]1[CH:3]=[C:4]2[NH:12][C:11]([CH2:13][CH2:14][CH2:15][CH3:16])=[N:10][C:5]2=[N:6][C:7]=1[CH:8]=[O:9]

Participants

4

Reactant 1

HCID 22100389HCID 22100389, compound

Product 1

HCID 21472345HCID 21472345, compoundYield 55.2%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

1.04 g (3.66 mmole) of the compound obtained in step 6 was dissolved in 5 ml of CH2Cl2 and thereto was added 3.2 g (36.6 mmole) of activated MnO2. The reaction solution was stirred for 16 hours at room temperature and filtered through Cellite. The resultant was concentrated under reduced pressure to obtain 0.57 g of the title compound (yield 55%).

Workup

  1. filtrationfiltered through Cellite
  2. concentrationThe resultant was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e393f566ed974dfbb2b804b85174d15c
Source dataset
uspto-grants-1997_11
Patent number
US05691348

Reaction notes

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