Hydrogen Bromide → HCID 178419243, compound

HRID 2295044Notes

Reaction equation

HRID 2295044 reaction equation
C(OC([N:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH:18][N:19]3[CH2:23][CH2:22][N:21]=[CH:20]3)=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=O)(C)(C)C.[BrH:24]>C(O)(=O)C>[BrH:24].[BrH:24].[CH3:17][C:16]1[C:11]2[NH:10][CH:9]=[N:8][C:12]=2[CH:13]=[CH:14][C:15]=1[NH:18][N:19]1[CH2:23][CH2:22][N:21]=[CH:20]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 677273531-Tert-butoxycarbonyl-4-methyl-5-(2-imidazolinylamino)benzimidazole

Product 1

HCID 178419243HCID 178419243, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of 1-tert-butoxycarbonyl-4-methyl-5-(2-imidazolinylamino)benzimidazole (2.40 g) in glacial acetic acid (50 mL) is added a solution of hydrobromic acid in glacial acetic acid (30%, 6 mL). The mixture is stirred at room temperature and gas evolution is monitored. After the gas evolution has stopped (about 1 hour), the precipitate is filtered and washed with ether. The solid is recrystallized from methanol/ether and dried in vacuo to afford 4-methyl-5-(2-imidazolinylamino)benzimidazole dihydrobromide as a pale rose solid.

Workup

  1. custom(about 1 hour)
  2. filtrationthe precipitate is filtered
  3. washwashed with ether
  4. customThe solid is recrystallized from methanol/ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-afba7d4e9db846e0b58b3b416d2ad086
Source dataset
uspto-grants-1997_11
Patent number
US05691370

Reaction notes

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