Hydrochloric Acid → HCID 131720336, compound

HRID 2295095Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[C:6]([CH:29]=[CH:30][CH:31]=1)[O:7][C:8]1[C:13]([C:14]([O:16]CC)=[O:15])=[CH:12][CH:11]=[C:10]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26](=[NH:28])[NH2:27])[CH:21]=2)[N:9]=1)(=[NH:3])[NH2:2].[ClH:32]>>[ClH:32].[ClH:32].[C:1]([C:4]1[CH:5]=[C:6]([CH:29]=[CH:30][CH:31]=1)[O:7][C:8]1[C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=[C:10]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26](=[NH:27])[NH2:28])[CH:21]=2)[N:9]=1)(=[NH:2])[NH2:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 10788206HCID 10788206, compound

Product 1

HCID 131720336HCID 131720336, compound

Conditions

Temperature: 80 °C

Procedure

In a manner similar to Example 2 above, 2,6-bis(3-amidinophenoxy)pyridine-3-carboxylic acid, ethyl ester (0.20 g, 0.31 mmol) was dissolved in 5M HCl and heated for 2 hours at 80° C. The solvent was removed in vacuo to give 2,6-bis(3-amidinophenoxy)pyridine-3-carboxylic acid, dihydrochloride; NMR (DMSO-d6) 9.5 (br s,4), 9.35 (br s,4), 8.45 (d,1), 7.7 (m,2), 7.6 (m,2), 7.5 (m,4), 6.95 (d,1) ppm.

Workup

customThe solvent was removed in vacuo

Sources & evidence

ORD record: ord-d861e12c4d0049be81cad68689f03ebf
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05691364

Reaction notes

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