HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-n-Butylpiperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Butyl iodide | HCID 10962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-n-Butylpiperazine dihydrochloride | HCID 22591405 | — |
Reaction Steps
To a dimethylformamide (7 ml) solution containing N-(tert-butoxycarbonyl)piperazine (1.0 g) were added potassium carbonate (742 mg) and then butyl iodide (1.09 g), and the mixture was stirred at room temperature for 15 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-N-butylpiperazine. This compound was acid-treated with hydrochloric acid to obtain N-butylpiperazine.dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849622B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-a101939f33274ce39472dcee1a489da3 |
| Source note | uspto-grants-2005_02 |