Hydrochloric Acid → 1-n-Butylpiperazine dihydrochloride

HRID 22952Notes

Reaction equation

HRID 22952 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.C(=O)([O-])[O-].[K+].[K+].[CH2:20](I)[CH2:21][CH2:22]C.[ClH:25]>CN(C)C=O>[ClH:25].[ClH:25].[CH2:6]([N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)[CH2:20][CH2:21][CH3:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 10962Butyl iodideHCID 11430Potassium CarbonateHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 225914051-n-Butylpiperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a dimethylformamide (7 ml) solution containing N-(tert-butoxycarbonyl)piperazine (1.0 g) were added potassium carbonate (742 mg) and then butyl iodide (1.09 g), and the mixture was stirred at room temperature for 15 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-N-butylpiperazine. This compound was acid-treated with hydrochloric acid to obtain N-butylpiperazine.dihydrochloride.

Workup

  1. customreaction

Sources & evidence

ORD record
ord-a101939f33274ce39472dcee1a489da3
Source dataset
uspto-grants-2005_02
Patent number
US06849622B2

Reaction notes

Loading…