Methyl chloroformate → 5,11-dihydro-11-methoxycarbonyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Reaction equation
[N:1]1[C:6]2[NH:7][C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[C:10](=[O:12])[NH:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:17](Cl)(=[O:20])[O:18][CH3:19]>O1CCOCC1.C1(C)C=CC=CC=1>[CH3:19][O:18][C:17]([N:7]1[C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](=[O:12])[NH:11][C:5]2[CH:4]=[CH:3][CH:2]=[N:1][C:6]1=2)=[O:20]Participants
5
Procedure
From 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and methyl chlorocarbonate in a mixture of dioxan and toluene, 5,11-dihydro-11-methoxycarbonyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one was obtained, m.p. 266°-267° C. (D) (from 1,2-dichloroethane);
Sources & evidence
- ORD record
- ord-36ff84d6262f4dc2a2913fe901010478
- Source dataset
- uspto-grants-1984_01
- Patent number
- US04424222
Reaction notes
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