Isonicotinoyl chloride hydrochloride → HCID 13282024, compound

HRID 2295296Notes

Reaction equation

HRID 2295296 reaction equation
Cl[C:2]1[S:3][CH:4]=[C:5]2[C:11](=[O:12])[NH:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[N:7]([C:17]([C:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH:20]=3)=[O:18])[C:6]=12.ClC1SC=C2C(=O)NC3C=CC=CC=3NC=12.Cl.C(Cl)(=O)C1C=CN=CC=1.ClC1SC=C2C(=O)NC3C=CC=CC=3N(C(C3C=CN=CC=3)=O)C=12>>[CH3:25][N:22]1[CH2:23][CH2:24][C:19]([C:17]([N:7]2[C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[NH:10][C:11](=[O:12])[C:5]3=[CH:4][S:3][CH:2]=[C:6]23)=[O:18])=[CH:20][CH2:21]1

Participants

5

Reactant 4

HCID 12262826Isonicotinoyl chloride hydrochlorideHCID 20387764HCID 20387764, compoundHCID 20475096HCID 20475096, compound2×HCID 20475110HCID 20475110, compound

Product 1

HCID 13282024HCID 13282024, compound

Procedure

3-chloro-4,9-dihydro-4-[(1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one, prepared from 3-chloro-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and isonicotinic acid chloride hydrochloride via 3-chloro-4,9-dihydro-4-[(4-pyridinyl)carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 3-chloro-4,9-dihydro-4-[(4-pyridinyl)carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one methoiodide.

Sources & evidence

ORD record
ord-ddc529bc90ae4c61923535cd1f741878
Source dataset
uspto-grants-1984_01
Patent number
US04424225

Reaction notes

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