Trifluoroacetic anhydride → HCID 178434138, compound

Participants

Reaction Steps

3.7 g (0.02 moles) of 3-methyl-1,4-dihydropyrido[3,4-e]-as-triazine hydrochloride are dissolved in 100 ml of trifluoroacetic acid, and the solution is maintained at room temperature for 2 hours. Thereafter 22.4 ml (0.08 moles) of trifluoroacetic acid anhydride are added to the mixture, and the reaction is conducted for additional 3 hours at 20° to 30° C. The reaction mixture is processed to obtain 5.4 g (75.5%) of 1-trifluoroacetyl-3-methyl-1,4-dihydropyrido[3,4-e]-as-triazine trifluoroacetate; m.p.: 208°-209° C.

Provenance & Evidence