Trifluoroacetic anhydride → HCID 178434138, compound

HRID 2295343Notes

Reaction equation

HRID 2295343 reaction equation
Cl.[CH3:2][C:3]1[NH:8][C:7]2[CH:9]=[N:10][CH:11]=[CH:12][C:6]=2[NH:5][N:4]=1.[F:13][C:14]([F:25])([F:24])[C:15]([O:17][C:18](=[O:23])[C:19]([F:22])([F:21])[F:20])=[O:16]>FC(F)(F)C(O)=O>[F:13][C:14]([F:25])([F:24])[C:15]([OH:17])=[O:16].[F:22][C:19]([F:20])([F:21])[C:18]([N:5]1[C:6]2[CH:12]=[CH:11][N:10]=[CH:9][C:7]=2[NH:8][C:3]([CH3:2])=[N:4]1)=[O:23]

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 178433915HCID 178433915, compound

Product 1

HCID 178434138HCID 178434138, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3.7 g (0.02 moles) of 3-methyl-1,4-dihydropyrido[3,4-e]-as-triazine hydrochloride are dissolved in 100 ml of trifluoroacetic acid, and the solution is maintained at room temperature for 2 hours. Thereafter 22.4 ml (0.08 moles) of trifluoroacetic acid anhydride are added to the mixture, and the reaction is conducted for additional 3 hours at 20° to 30° C. The reaction mixture is processed to obtain 5.4 g (75.5%) of 1-trifluoroacetyl-3-methyl-1,4-dihydropyrido[3,4-e]-as-triazine trifluoroacetate; m.p.: 208°-209° C.

Sources & evidence

ORD record
ord-051931b29b084b4db1f7b417b38c3e71
Source dataset
uspto-grants-1984_01
Patent number
US04424351

Reaction notes

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