Acetic Anhydride → HCID 13136404, compound

HRID 2295349Notes

Reaction equation

HRID 2295349 reaction equation
Cl.[CH2:2]([C:10]1[NH:11][NH:12][C:13]2[CH:19]=[CH:18][N:17]=[CH:16][C:14]=2[N:15]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[C:20](OC(=O)C)(=[O:22])[CH3:21].C([O-])(O)=O.[Na+]>>[CH2:2]([C:10]1[NH:11][N:12]([C:20](=[O:22])[CH3:21])[C:13]2[CH:19]=[CH:18][N:17]=[CH:16][C:14]=2[N:15]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 12340885HCID 12340885, compound

Product 1

HCID 13136404HCID 13136404, compoundYield 75%

Procedure

3-Octyl-1,2-dihydropyrido[3,4-e]-as-triazine hydrochloride is reacted with acetic anhydride as described in Example 1, and the resulting salt is treated with a solution of sodium hydrocarbonate to obtain 3-octyl-1-acetyl-1,2-dihydropyrido[3,4-e]-as-triazine with a yield of 75%. This compound is reacted with an equimolar amount of fumaric acid in ethanol to obtain the hydrogen fumarate melting at 285°-287° C.

Sources & evidence

ORD record
ord-7bf8bd40f6244b83a00e8beee4fd61a3
Source dataset
uspto-grants-1984_01
Patent number
US04424351

Reaction notes

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