Potassium Carbonate → 2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 30 parts of potassium valinate, 15 parts of p-fluoro-benzotrifluoride, 7 parts of dichlorohexano-18-crown-6 ether catalyst, 10 parts of potassium carbonate and 126 parts of sulfolane was placed in a pressure reactor. The reactor was degassed, placed under an argon atmosphere and sealed. The reaction mixture was then heated and maintained at about 100° C. for about 15 hours. Analysis of the reaction product indicated a 7.0% yield of 2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid based on p-fluorobenzotrifluoride starting material.

Provenance & Evidence