4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene → 4-Fluoro-3-nitrobenzotrifluoride

Participants

Reaction Conditions

Reaction Steps

A mixture of 22.6 parts of 4-chloro-3-nitrobenzotrifluoride, 9.3 parts of potassium fluoride, and 1.4 parts of tetramethylammonium bromide catalyst was heated and maintained at about 165.0° C. for about 9 hours. The reaction mixture was then cooled to room temperature and filtered. The filtrate was distilled under reduced pressure to yield 161 parts of 4-fluoro-3-nitrobenzotrifluoride.

Provenance & Evidence