4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene → 4-Fluoro-3-nitrobenzotrifluoride
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[F-:15].[K+]>[Br-].C[N+](C)(C)C>[F:15][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 165 °C
Procedure
A mixture of 22.6 parts of 4-chloro-3-nitrobenzotrifluoride, 9.3 parts of potassium fluoride, and 1.4 parts of tetramethylammonium bromide catalyst was heated and maintained at about 165.0° C. for about 9 hours. The reaction mixture was then cooled to room temperature and filtered. The filtrate was distilled under reduced pressure to yield 161 parts of 4-fluoro-3-nitrobenzotrifluoride.
Workup
- temperaturewas heated
- temperatureThe reaction mixture was then cooled to room temperature
- filtrationfiltered
- distillationThe filtrate was distilled under reduced pressure
Sources & evidence
- ORD record
- ord-e1705cc64b244adb9393aae3bcc9ff47
- Source dataset
- uspto-grants-1984_01
- Patent number
- US04424396
Reaction notes
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