Phosphorus pentachloride → Benzene, 2-chloro-1-fluoro-4-(trifluoromethyl)-

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Reaction Steps

Nine parts of the 4-fluoro-3-nitrobenzotrifluoride of Example I, and six parts of phosphorous pentachloride were sealed tightly under a nitrogen atmosphere in a tubular reactor. The sealed reactor was heated in an oil bath for about two hours at 170°-180° C. The reaction mixture was poured into water and extracted with diethyl ether. The organic layer was dried and distilled at atmospheric pressure to yield 13.6 parts of 3-chloro-4-fluorobenzotrifluoride. The structure was confirmed by gas chromatography--mass spectrum, and by F19 and C13NMR analyses.

Provenance & Evidence