Sodium Bicarbonate → HCID 23721273, compound

HRID 2295417Notes

Reaction equation

[C:1]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH2:9][CH:10]([OH:29])[CH2:11][O:12][C:13]2[C:22]([CH2:23][CH2:24][CH3:25])=[C:21]3[C:16]([CH:17]=[CH:18][C:19]([C:26]([OH:28])=[O:27])=[CH:20]3)=[CH:15][CH:14]=2)=[C:6]([CH2:32][CH2:33][CH3:34])[C:5]=1[OH:35])(=[O:3])[CH3:2].C(=O)(O)[O-].[Na+:40]>>[C:1]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH2:9][CH:10]([OH:29])[CH2:11][O:12][C:13]2[C:22]([CH2:23][CH2:24][CH3:25])=[C:21]3[C:16]([CH:17]=[CH:18][C:19]([C:26]([O-:28])=[O:27])=[CH:20]3)=[CH:15][CH:14]=2)=[C:6]([CH2:32][CH2:33][CH3:34])[C:5]=1[OH:35])(=[O:3])[CH3:2].[Na+:40]

Participants

Reactant 2

HCID 516892Sodium Bicarbonate

HCID 20282932HCID 20282932, compound

Product 1

HCID 23721273HCID 23721273, compoundYield 85.7%

Procedure

7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-8-propylnaphthalene-2-carboxylic acid (9.377 g) was treated with an aqueous solution of sodium bicarbonate (1.640 g) and the resulting solution was freeze-dried to afford sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-8-propylnaphthalene-2-carboxylate (8.4 g).

Workup

customthe resulting solution was freeze-dried

Sources & evidence

ORD record: ord-361ebbfb8fcb4ed58be75a63f9b55cc6
Source dataset: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04424231

Reaction notes

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