反应详情

80.1 g of 3,3-dimethyl-4-(4'-chloro-phenacyl)-γ-butyrolactone were dissolved in 500 ml of ethanol, and dry hydrogen chloride was passed in until the temperature had reached 50° C. A slow stream of hydrogen chloride was then passed through the solution at 50° C., initially with cooling, for 3 hours, and the introduction was then continued until the mixture had reached room temperature again. Distilling off the ethanol in vacuo gave 100 g of 6-(4'-chloro-phenyl)-6-oxo-4-chloro-3,3-dimethyl-hexanoic acid ethyl ester of refractive index nD20 =1.528.

1. customhad reached 50° C
2. customwas then passed through the solution at 50° C.
3. temperatureinitially with cooling, for 3 hours
4. customhad reached room temperature
5. distillationDistilling off the ethanol in vacuo