2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20473866, compound

HRID 2295741Notes

Reaction equation

HRID 2295741 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[CH2:17]([O:24][C:25]1[CH:26]=[C:27]([CH:36]=[CH:37][CH:38]=1)[C:28]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)=[O:29])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CC(C)C>[OH2:12].[ClH:16].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:33]2[CH2:32][CH2:31][N:30]([C:28](=[O:29])[C:27]3[CH:36]=[CH:37][CH:38]=[C:25]([O:24][CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:26]=3)[CH2:35][CH2:34]2)[N:3]=1

Participants

4

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 13053543HCID 13053543, compound

Product 1

HCID 20473866HCID 20473866, compoundYield 163.8%

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

To 70 ml of isopentanol were added 3.48 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 3.93 g of 1-(3-benzyloxybenzoyl)piperazine, and the resulting mixture was heated under reflux for 4 hours. After cooling the mixture, the crystals which were produced were collected by filtration and then recrystallized from ethanol, to give 6.59 g of the desired Compound No. 13 hydrochloride hydrate in the form of pale yellow prisms melting at 180°-182° C. (with decomposition).

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 4 hours
  3. temperatureAfter cooling the mixture
  4. customthe crystals which were produced
  5. filtrationwere collected by filtration
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-76ef7ee77200435d8670d08a3164e981
Source dataset
uspto-grants-1984_01
Patent number
US04426382

Reaction notes

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