2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20473866, compound

Participants

Reaction Steps

To 70 ml of isopentanol were added 3.48 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 3.93 g of 1-(3-benzyloxybenzoyl)piperazine, and the resulting mixture was heated under reflux for 4 hours. After cooling the mixture, the crystals which were produced were collected by filtration and then recrystallized from ethanol, to give 6.59 g of the desired Compound No. 13 hydrochloride hydrate in the form of pale yellow prisms melting at 180°-182° C. (with decomposition).

Provenance & Evidence