2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20473803, compound

Participants

Reaction Steps

To 25 ml of isopentanol were added 1.2 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 1.55 g of 1-(1-phenylcyclopentylcarbonyl)piperazine, and the resulting mixture was heated under reflux for 4 hours. The crystals thus produced were collected by filtration and recrystallized from 50% v/v aqueous ethanol, to give 1.90 g of the desired compound No. 60 hydrochloride hydrate in the form of colourless powdery crystals melting at 277°-278° C. (with decomposition).

Provenance & Evidence