Water → HCID 20474106, compound

HRID 2295829Notes

Reaction equation

HRID 2295829 reaction equation
O.[F:2][C:3]([F:20])([F:19])[C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[CH2:7][N:8]1[N:15]=[CH:14][C:12](=[O:13])[NH:11][C:9]1=[O:10]>[Zn].C(O)(=O)C>[F:19][C:3]([F:2])([F:20])[C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[CH2:7][N:8]1[C:9](=[O:10])[NH:11][C:12](=[O:13])[CH2:14][NH:15]1

Participants

5

Reactant 2

HCID 962WaterHCID 20474103HCID 20474103, compound

Product 1

HCID 20474106HCID 20474106, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

A 1 liter three-necked flask equipped with a mechanical stirrer was charged with 300 ml of water and 60 ml of glacial acetic acid. 3 g of 1-(3'-trifluoromethylbenzyl)-6-aza uracil was added in one portion followed by the addition of 3.3 g of zinc powder in small portions. After the addition was terminated the mixture was stirred vigorously and refluxed for 36 hours after which the mixture was cooled in ice and filtered. The crystals obtained were recrystallized from iso-propanol to give 1.5 g (50%) of 2-(3'-trifluoromethylbenzyl)-hexahydro-1,2,4-triazine-3,5-dione; m.p. 152°.

Workup

  1. customA 1 liter three-necked flask equipped with a mechanical stirrer
  2. additionAfter the addition
  3. customwas terminated the mixture
  4. temperaturerefluxed for 36 hours after which the mixture
  5. temperaturewas cooled in ice
  6. filtrationfiltered
  7. customThe crystals obtained
  8. customwere recrystallized from iso-propanol

Sources & evidence

ORD record
ord-13152a117f3c456a857245108162f9e4
Source dataset
uspto-grants-1984_01
Patent number
US04426522

Reaction notes

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