Water → HCID 20474106, compound

Participants

Reaction Steps

A 1 liter three-necked flask equipped with a mechanical stirrer was charged with 300 ml of water and 60 ml of glacial acetic acid. 3 g of 1-(3'-trifluoromethylbenzyl)-6-aza uracil was added in one portion followed by the addition of 3.3 g of zinc powder in small portions. After the addition was terminated the mixture was stirred vigorously and refluxed for 36 hours after which the mixture was cooled in ice and filtered. The crystals obtained were recrystallized from iso-propanol to give 1.5 g (50%) of 2-(3'-trifluoromethylbenzyl)-hexahydro-1,2,4-triazine-3,5-dione; m.p. 152°.

Provenance & Evidence