Trityl chloride → HCID 22825273, compound

HRID 2295843Notes

Reaction equation

HRID 2295843 reaction equation
[CH2:1]([O:15][CH2:16][C@H:17]([CH2:19][OH:20])[OH:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[C:21]1([C:27]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)Cl)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>N1C=CC=CC=1>[CH2:1]([O:15][CH2:16][C@H:17]([CH2:19][O:20][C:27]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[OH:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 6456Trityl chlorideHCID 12896846(2S)-3-(Tetradecyloxy)propane-1,2-diol

Product 1

HCID 22825273HCID 22825273, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In 30 ml of dry pyridine, 2.82 g of 1-tetradecyl-sn-glycerol is allowed to react 3.27 g of triphenylchloromethane to give 1-tetradecyl-3-trityl-sn-glycerol. This compound is subjected to methylation with methyl iodide and deprotection to give 2 g of 1-tetradecyl-2-methyl-sn-glycerol.

Sources & evidence

ORD record
ord-0f4849fc3f0f42719e36d4902bfa00c4
Source dataset
uspto-grants-1984_01
Patent number
US04426525

Reaction notes

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