Pyridine → [3-(2-Furanyl)phenyl]methyl cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

HRID 2295858ノート

反応式

HRID 2295858 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=1.N1C=CC=CC=1.[Cl:20][C:21]([Cl:31])=[CH:22][C@@H:23]1[C@H:25]([C:26](Cl)=[O:27])[C:24]1([CH3:30])[CH3:29]>C1(C)C=CC=CC=1>[Cl:20][C:21]([Cl:31])=[CH:22][C@@H:23]1[C@H:25]([C:26]([O:13][CH2:12][C:8]2[CH:9]=[CH:10][CH:11]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[CH:7]=2)=[O:27])[C:24]1([CH3:29])[CH3:30]

参加物

5

反応物 3

HCID 1049PyridineHCID 11116545[3-(2-Furyl)phenyl]methanolHCID 12617358cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropylcarbonyl chloride

生成物 1

HCID 86739183[3-(2-Furanyl)phenyl]methyl cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate収率 94.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

This reaction was conducted in the manner of Example 3, Step 2 using 1.5 g (0.009 mol) of 3-(2-furanyl)phenylmethanol, 0.7 g (0.009 mol) of pyridine, 50 mL of toluene, and 2.0 g (0.009 mol) of cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl chloride. The crude oily product was subjected to distillation under reduced pressure to give 3.1 g of [3-(2-furanyl)phenyl]methyl cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate, b.p. 160° C./0.1 mm.

後処理

  1. distillationThe crude oily product was subjected to distillation under reduced pressure

出典と根拠

ORDレコード
ord-9794dc515889405e8a968ebbda451b77
出典データセット
uspto-grants-1984_01
特許番号
US04426524

反応ノート

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