Methylamine → N-Cyano-N'-methyl-N"-[2-((4-methoxy-2-pyridyl)methylthio)ethyl]guanidine

HRID 2295884Notes

Reaction equation

HRID 2295884 reaction equation
[CH3:1][NH2:2].[C:3]([NH:5][C:6](=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][N:15]=1)SC)#[N:4]>C(O)C>[C:3]([NH:5][C:6]([NH:2][CH3:1])=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][N:15]=1)#[N:4]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20474239HCID 20474239, compound

Product 1

HCID 178484980N-Cyano-N'-methyl-N"-[2-((4-methoxy-2-pyridyl)methylthio)ethyl]guanidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Methylamine in ethanol (33%, 20 cc) was added to a stirred solution of N-cyano-N'-[2-((4-methoxy-2-pyridyl) methylthio)ethyl]-S-methylisothiourea (3.56 g) in ethanol (25 cc) at 35°, and the mixture was left to stand overnight. Nitrogen was bubbled through the solution and the crystals were filtered off to give the title product, (2.74 g) m.p. 121°-122°.

Workup

  1. waitthe mixture was left
  2. customNitrogen was bubbled through the solution
  3. filtrationthe crystals were filtered off

Sources & evidence

ORD record
ord-1f36bba02f5d45529123795cc7675610
Source dataset
uspto-grants-1984_01
Patent number
US04426526

Reaction notes

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