Methyl iodide → HCID 13336598, compound

HRID 2295948Notes

Reaction equation

HRID 2295948 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N:15]([CH3:17])[CH3:16])[CH:10]=2)=[N:6][CH:7]=1.[CH3:18][I:19]>CCOCC>[I-:19].[Cl:1][C:2]1[CH:7]=[N:6][C:5]([O:8][C:9]2[CH:10]=[C:11]([N+:15]([CH3:18])([CH3:17])[CH3:16])[CH:12]=[CH:13][CH:14]=2)=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13336583HCID 13336583, compound

Product 1

HCID 13336598HCID 13336598, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 5-chloro-2-(3-dimethylaminophenoxy)pyrimidine (3.75 g) and methyl iodide (4.50 g) in ether (25 ml) was stirred at room temperature for one week. Filtration of the ether solution gave 2.75 g (47%) of the title compound, mp 155° C.

Workup

  1. filtrationFiltration of the ether solution

Sources & evidence

ORD record
ord-0a99986422ab4ae38529718c07c0ac99
Source dataset
uspto-grants-1984_01
Patent number
US04427437

Reaction notes

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