反应详情

温度

140 °C

To a solution of 148 mg of ethyl[2-[2-(5-cyano-2-methoxybenzenesulfonylamino)ethyl]-5-isopropylphenoxy]acetate in 3 mL of N,N-dimethylformamide was added 41 mg of lithium chloride, and the mixture was stirred at 140° C. for 3 hours. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. To the residue was added aqueous 10% citric acid solution to adjust pH4, and the mixture was extracted with 100 mL of ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 139 mg of ethyl[2-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-5-isopropylphenoxy]acetate.

1. temperatureAfter being cooled to room temperature
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added aqueous 10% citric acid solution
4. extractionthe mixture was extracted with 100 mL of ethyl acetate
5. washThe organic layer was washed with water and brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was removed under reduced pressure