HCID 86738654, compound → HCID 67880269, compound

HRID 2296032Notes

Reaction equation

[C:1]([O:4][C@H:5]1[CH2:22][C@@:20]2([CH3:21])[C@@H:16]([CH2:17][CH2:18][C:19]2(SCC)[S:23][CH2:24][CH3:25])[C@H:15]2[C@@:6]1([F:31])[C@:7]1([CH3:30])[C:12]([CH2:13][CH2:14]2)=[CH:11][C:10](=[O:29])[CH:9]=[CH:8]1)(=[O:3])[CH3:2]>C(C1C=CC=CC=1CC)C>[C:1]([O:4][C@H:5]1[CH2:22][C@@:20]2([CH3:21])[C@@H:16]([CH2:17][CH:18]=[C:19]2[S:23][CH2:24][CH3:25])[C@H:15]2[C@@:6]1([F:31])[C@:7]1([CH3:30])[C:12]([CH2:13][CH2:14]2)=[CH:11][C:10](=[O:29])[CH:9]=[CH:8]1)(=[O:3])[CH3:2]

Participants

Conditions

Temperature: 180 °C

Procedure

A suspension of 5.2 g of 11β-(acetyloxy)-17,17-bis(ethylthio)-9-fluoroandrosta-1,4-dien-3-one in 85 ml of dry diethylbenzene was stirred at 180° C. (oil bath temperature) for 1.0 hour; the suspension gradually became a homogeneous solution during the heating. The resulting solution was cooled to 0° C. and the solid that precipitated was filtered and dried in vacuo to give 3.6 g of the title compound, melting point 211°-214° C.

Workup

temperatureThe resulting solution was cooled to 0° C.
customthe solid that precipitated
filtrationwas filtered
customdried in vacuo

Sources & evidence

ORD record: ord-25f9fccd80dc4e8ebde326d88801c880
Source dataset: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04427592

Reaction notes

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