反应详情

Paracresol 34.15 g (316.0 mmol), Amberlyst 15E 2.50 g, and toluene 20 ml were charged in a sufficiently dried 200 ml reactor purged with argon, 30 ml of a toluene solution containing 4-cumylphenol 14.40 g (105.5 mmol) was added dropwise to the reactor at 80° C. and then the resultant mixture was stirred for 17 hours. After cooling to a room temperature, the resultant mixture was filtered while being washed with hexane. The obtained liquid was purified by silica gel column chromatography to obtain 2-cumyl-4-methylphenol 10.52 g (44%).

1. custompurged with argon, 30 ml of a toluene solution
2. additionwas added dropwise to the reactor at 80° C.
3. filtrationthe resultant mixture was filtered
4. washwhile being washed with hexane
5. customThe obtained liquid was purified by silica gel column chromatography