Hydrochloric Acid → HCID 13084583, compound

Participants

Reaction Steps

2.0 g (0.021 mole) of guanidine hydrochloride and 0.042 mole of a 30% strength sodium methylate solution are added to 10.0 g (0.021 mole) of 1-[2-(3-dimethylamino-1-oxo-propenyl)-phenoxy]-3-[4-(4-chlorophenyl)-piperazin-1-yl]-propan-2-ol.HCl in 250 ml of ethanol, and the mixture is refluxed for 12 hours. The hot solution is filtered and the filtrate is concentrated. The crude product is recrystallized from ethanol, and 3.5 g (38%) of product of melting point 159°-160° C. are isolated.

Provenance & Evidence