Hydrochloric Acid → HCID 13084583, compound

HRID 2296340Notes

Reaction equation

HRID 2296340 reaction equation
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].C[O-].[Na+].CN(C)[CH:11]=[CH:12][C:13]([C:15]1[CH:38]=[CH:37][CH:36]=[CH:35][C:16]=1[O:17][CH2:18][CH:19]([OH:34])[CH2:20][N:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=2)[CH2:23][CH2:22]1)=O.Cl>C(O)C>[NH2:4][C:3]1[N:5]=[C:13]([C:15]2[CH:38]=[CH:37][CH:36]=[CH:35][C:16]=2[O:17][CH2:18][CH:19]([OH:34])[CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:27]3[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=3)[CH2:25][CH2:26]2)[CH:12]=[CH:11][N:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 56627760HCID 56627760, compound

Product 1

HCID 13084583HCID 13084583, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.0 g (0.021 mole) of guanidine hydrochloride and 0.042 mole of a 30% strength sodium methylate solution are added to 10.0 g (0.021 mole) of 1-[2-(3-dimethylamino-1-oxo-propenyl)-phenoxy]-3-[4-(4-chlorophenyl)-piperazin-1-yl]-propan-2-ol.HCl in 250 ml of ethanol, and the mixture is refluxed for 12 hours. The hot solution is filtered and the filtrate is concentrated. The crude product is recrystallized from ethanol, and 3.5 g (38%) of product of melting point 159°-160° C. are isolated.

Workup

  1. filtrationThe hot solution is filtered
  2. concentrationthe filtrate is concentrated
  3. customThe crude product is recrystallized from ethanol, and 3.5 g (38%) of product of melting point 159°-160° C.
  4. customare isolated

Sources & evidence

ORD record
ord-798fe9328a9a44329990d1750b0dada4
Source dataset
uspto-grants-1984_01
Patent number
US04428950

Reaction notes

Loading…