Diphenyl Ether → HCID 13060553, compound

HRID 2296460Notes

Reaction equation

HRID 2296460 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:16][CH:17]=[C:18]([C:23]([O:25][CH3:26])=[O:24])[C:19]([O:21]C)=O)(=[O:4])=[O:3].C1(OC2C=CC=CC=2)C=CC=CC=1>>[O:21]=[C:19]1[N:10]2[CH:11]=[N:12][C:13]3[CH:14]=[CH:15][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:7][C:8]=3[C:9]2=[N:16][CH:17]=[C:18]1[C:23]([O:25][CH3:26])=[O:24]

Participants

3

Reactant 2

HCID 7583Diphenyl EtherHCID 13060505HCID 13060505, compound

Product 1

HCID 13060553HCID 13060553, compoundYield 71.6%

Conditions

Temperature
250 °C

Procedure

A mixture of dimethyl [{6-methanesulfonamido-4-quinazolinylamino)methylene]propanedioate (7.2 g) and diphenyl ether (43 ml) was stirred at 250° C. for 15 minutes and then cooled to ambient temperature to give crystals, which were filtered off and washed with a mixture of chloroform and methanol to give crystalline methyl 4-oxo-10-methanesulfonamido-4H-pyrimido[1,2-c]quinazoline-3-carboxylate (4.72 g).

Workup

  1. temperaturecooled to ambient temperature
  2. customto give crystals, which
  3. filtrationwere filtered off
  4. washwashed with a mixture of chloroform and methanol

Sources & evidence

ORD record
ord-ea857f7801404e8ba5d9fa855a8e6fde
Source dataset
uspto-grants-1984_01
Patent number
US04429126

Reaction notes

Loading…