反应详情

温度

120 °C

A mixture of methyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (3.2 g), anhydrous lithium iodide (8.0 g) and dry pyridine (32 ml) was stirred at 120° C. for 1.5 hours. The reaction mixture was concentrated under reduced pressure to give a residue, which was dissolved in water. Insoluble materials were removed by filtration. The aqueous layer was adjusted to pH 1-2 with conc. hydrochloric acid to give crystals, which were separated by filtration and dried. The crude crystals were washed with methanol three times and recrystallized from acetonitrile to give 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylic acid (0.7 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customto give a residue, which
3. customInsoluble materials were removed by filtration
4. customto give crystals, which
5. customwere separated by filtration
6. customdried
7. washThe crude crystals were washed with methanol three times
8. customrecrystallized from acetonitrile