Hydrochloric Acid → HCID 19848353, compound

HRID 2296492Notes

Reaction equation

HRID 2296492 reaction equation
[C:1]([C:3]1[C:4]([I:16])=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:6]([I:10])=[CH:7][C:8]=1[I:9])#[N:2].[OH-:17].[Na+].Cl>O>[C:1]([C:3]1[C:4]([I:16])=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:6]([I:10])=[CH:7][C:8]=1[I:9])(=[O:17])[NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19848370HCID 19848370, compound

Product 1

HCID 19848353HCID 19848353, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

30 g of 3-(3-cyano-2,4,6-triiodophenyl)propionic acid is introduced into a solution of 8 g of caustic soda in 100 ml of water. The solution is then maintained for 3 hours at 60° C., decolorized by repeated treatment with active carbon, and brought to pH 1 by adding concentrated hydrochloric acid. After several hours of agitation in an ice bath, the precipitate is vacuum-filtered, washed with water, and dried at 50° C. Yield: 29 g (94% of theory) of 3-(3-carbamoyl-2,4,6-triiodophenyl)propionic acid as a white powder, mp>280° C.

Workup

  1. waitAfter several hours of agitation in an ice bath
  2. filtrationthe precipitate is vacuum-filtered
  3. washwashed with water
  4. customdried at 50° C

Sources & evidence

ORD record
ord-e1a0198e8c494faf915b208ec5c3b0a3
Source dataset
uspto-grants-1984_01
Patent number
US04429152

Reaction notes

Loading…