HCID 9865354, compound → HCID 22319132, compound

HRID 229654Notes

Reaction equation

HRID 229654 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[C:10](=[O:30])[N:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-])=O)[CH:14]=1)#[N:2].[H][H]>C(OCC)(=O)C.[C].[Pd]>[NH2:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:13]1[CH:14]=[C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:1]#[N:2])[C:10](=[O:30])[N:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:12]=1

Participants

5

Reactant 2

HCID 9865354HCID 9865354, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22319132HCID 22319132, compoundYield 67.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

3-(2-Cyanophenyl)-5-(2-nitrophenyl)-1-phenyl-1,2-dihydropyridin-2-one (32 mg) was dissolved in 15 ml of ethyl acetate, 5 mg of 10% palladium-carbon (water-containing substance) were added and the mixture was stirred at room temperature in a hydrogen atmosphere for 15 minutes. The catalyst was filtered off and the solvent was evaporated in vacuo to give 20 mg of the title compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-0e9a917f3c1c4d70853b1a3ff4767a95
Source dataset
uspto-grants-2009_07
Patent number
US07563811B2

Reaction notes

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