Hydrogen chloride-ethyl acetate → HCID 69972355, compound

HRID 2296649Notes

Reaction equation

HRID 2296649 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([CH3:17])(=[O:16])=[O:15])[CH2:10][C@@H:9]1[C:18]([OH:20])=[O:19])=O)(C)(C)C.[ClH:21].CCOC(C)=O>>[ClH:21].[CH3:17][S:14]([N:11]1[CH2:12][CH2:13][NH:8][C@@H:9]([C:18]([OH:20])=[O:19])[CH2:10]1)(=[O:15])=[O:16]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 54309376HCID 54309376, compound

Product 1

HCID 69972355HCID 69972355, compound

Procedure

A solution of (2R)-1-tert-butoxycarbonyl-4-methanesulfonylpiperazine-2-carboxylic acid (2.90 g) in 4N HCl-AcOEt solution (40 ml) was stirred at room temperature for 30 minutes. The solution was concentrated in vacuo and the residue was solidified with Et2O to give 2.15 g of (2R)-4-methanesulfonylpiperazine-2-carboxylic acid hydrochloride as a powder.

Workup

  1. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-69fb49b3ebeb4d8c91123954b0f7fc84
Source dataset
uspto-grants-2002_12
Patent number
US06489324B2

Reaction notes

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