Dimethylformamide → HCID 21983734, compound

HRID 2296676Notes

Reaction equation

HRID 2296676 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][S:9]([OH:12])(=O)=[O:10].CN(C=O)C.S(Cl)([Cl:20])=O>>[ClH:20].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][S:9]([Cl:20])(=[O:12])=[O:10]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 967242-Pyridineethanesulfonic acid

Product 1

HCID 21983734HCID 21983734, compound

Conditions

Temperature
50 °C

Procedure

2-(2-Pyridyl)ethanesulfonic acid (1.00 g) was suspended in thionyl chloride (5 ml). Catalytic amount of DMF was added to the suspension. The mixture was stirred at 50° C. for 30 minutes, and was concentrated in vacuo. The resulting solid was recovered and washed with Et2O to give 1.41 g of 2-(2-pyridyl)ethanesulfonyl chloride hydrochloride as a solid.

Workup

  1. concentrationwas concentrated in vacuo
  2. customThe resulting solid was recovered
  3. washwashed with Et2O

Sources & evidence

ORD record
ord-3df39d26657f48aabc8ad6f773f41f79
Source dataset
uspto-grants-2002_12
Patent number
US06489324B2

Reaction notes

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