5-Amino-6-nitro-4(3H)-quinazolinone → HCID 135813643, compound

HRID 2296711Notes

Reaction equation

HRID 2296711 reaction equation
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:15])[NH:5][CH:6]=[N:7]2>CO.[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:15])[NH:5][CH:6]=[N:7]2

Participants

4

Reactant 1

HCID 1358136425-Amino-6-nitro-4(3H)-quinazolinone

Product 1

HCID 135813643HCID 135813643, compoundYield 98.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of the above amine (250 mg, 1.21 mmol) in MeOH (50 mL) was hydrogenated over 10% Pd/C (50 mg) at 50 psi for 5 h. The catalyst was removed by filtration and the filtrate concentrated to yield 5,6-diaminoquinazolin-4-one (210 mg, 98% crude).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-bd5e130e88eb46dabd5e0f3d31341743
Source dataset
uspto-grants-2002_12
Patent number
US06489328B2

Reaction notes

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