Methanol → HCID 70077352, compound

HRID 2296752Notes

Reaction equation

HRID 2296752 reaction equation
[OH-:1].[Na+].C([CH2:5][CH2:6][CH:7]1[CH:13]=[CH:12][N:11]([C:14](=[O:36])[C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:35])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:17][CH:16]=2)[C:10]2[CH:37]=[CH:38][CH:39]=[CH:40][C:9]=2[S:8]1)#N.[CH3:41][OH:42]>>[C:41]([CH2:5][CH2:6][CH:7]1[CH:13]=[CH:12][N:11]([C:14](=[O:36])[C:15]2[CH:16]=[CH:17][C:18]([NH:21][C:22](=[O:35])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[CH:19][CH:20]=2)[C:10]2[CH:37]=[CH:38][CH:39]=[CH:40][C:9]=2[S:8]1)([OH:42])=[O:1]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 18387429HCID 18387429, compound

Product 1

HCID 70077352HCID 70077352, compound

Procedure

A 6.6N NaOH solution (0.5 ml) was added to a mixture of Compound 30 as prepared in Example 17 (0.05 g, 0.096 mM) in methanol. The mixture was stirred at reflux overnight, cooled to room temperature and evaporated in vacuo. The residue was diluted with water and enough 6N HCl was added drop-wise to precipitate the product. The solid product was collected by filtration and dried. m/z (MH+)537

Workup

  1. temperatureat reflux overnight
  2. customevaporated in vacuo
  3. additionThe residue was diluted with water and enough 6N HCl
  4. additionwas added drop-wise
  5. customto precipitate the product
  6. filtrationThe solid product was collected by filtration
  7. customdried

Sources & evidence

ORD record
ord-1d5a6680d73e4dcf8ec6b230d4dfabf9
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

Loading…