2-Methylbenzoyl chloride → HCID 18387444, compound

HRID 2296754Notes

Reaction equation

HRID 2296754 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[S:5][C:6]2[CH:23]=[CH:22][CH:21]=[CH:20][C:7]=2[N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)[C:9](=[O:11])[CH:10]=1.[C:24]1([CH3:33])[C:25]([C:30](Cl)=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=1.C1(C2C=CC=CC=2C(Cl)=O)C=CC=CC=1>>[OH:1][CH2:2][CH2:3][C:4]1[S:5][C:6]2[CH:23]=[CH:22][CH:21]=[CH:20][C:7]=2[N:8]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([NH:19][C:30](=[O:31])[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH3:33])=[CH:17][CH:18]=2)[C:9](=[O:11])[CH:10]=1

Participants

4

Reactant 3

HCID 702762-Methylbenzoyl chlorideHCID 12563768[1,1'-Biphenyl]-2-carbonyl chlorideHCID 18387440HCID 18387440, compound

Product 1

HCID 18387444HCID 18387444, compoundYield 64%

Procedure

2-(2-Hydroxyethyl)-5-(4-aminobenzyl)-1,5-benzothiazepine-4-one as prepared in Example 21 (0.105 g, 0.31 mM) was treated using the procedure described in Example 22, with o-toluoyl chloride (0.04 ml, 0.33 mM) substituted for 2-phenylbenzoyl chloride, to yield the title product as a white solid (0.086 g, 64%) m/z (MH+) 447

Workup

  1. additionwas treated

Sources & evidence

ORD record
ord-0e4cd01fe50a465886d393c0bdc029c0
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

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