2-Methylbenzoyl chloride → 2-(2-Hydroxyethyl)-5-[4-(2-methylbenzoylamino)benzene-sulfonyl]-1,5-benzothiazepine

HRID 2296758Notes

Reaction equation

HRID 2296758 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH:10]=[CH:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[S:5]1.[C:25]1([CH3:34])[C:26]([C:31](Cl)=[O:32])=[CH:27][CH:28]=[CH:29][CH:30]=1.C1(C2C=CC=CC=2C(Cl)=O)C=CC=CC=1>>[OH:1][CH2:2][CH2:3][CH:4]1[CH:10]=[CH:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:31](=[O:32])[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[CH3:34])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[S:5]1

Participants

4

Reactant 3

HCID 702762-Methylbenzoyl chlorideHCID 12563768[1,1'-Biphenyl]-2-carbonyl chlorideHCID 183874372-(2-Hydroxyethyl)-5-(4-aminobenzenesulfonyl)-1,5-benzothiazepine

Product 1

HCID 183874302-(2-Hydroxyethyl)-5-[4-(2-methylbenzoylamino)benzene-sulfonyl]-1,5-benzothiazepine

Procedure

Compound 4 as prepared in Example 25 (0.55 g, 1.5 mM) was treated as described in Example 26 with 2-toluoyl chloride (0.3 ml) substituted for 2-phenylbenzoyl chloride to give the desired product m/z (MH+)483

Workup

  1. additionwas treated

Sources & evidence

ORD record
ord-4c8fa763d08c426892ed575af4db55e4
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

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