Benzoyl chloride, 3,4-dichloro- → 2-(2-Hydroxyethyl)-5-[4-(3,4-dichlorobenzoylamino)benzene-sulfonyl]-1,5-benzothiazepine

HRID 2296759Notes

Reaction equation

HRID 2296759 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH:10]=[CH:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[S:5]1.[Cl:25][C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][C:34]=1[Cl:35])[C:29](Cl)=[O:30].C1(C2C=CC=CC=2C(Cl)=O)C=CC=CC=1>>[OH:1][CH2:2][CH2:3][CH:4]1[CH:10]=[CH:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:29](=[O:30])[C:28]3[CH:32]=[CH:33][C:34]([Cl:35])=[C:26]([Cl:25])[CH:27]=3)=[CH:16][CH:15]=2)(=[O:13])=[O:12])[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[S:5]1

Participants

4

Reactant 3

HCID 76403Benzoyl chloride, 3,4-dichloro-HCID 12563768[1,1'-Biphenyl]-2-carbonyl chlorideHCID 183874372-(2-Hydroxyethyl)-5-(4-aminobenzenesulfonyl)-1,5-benzothiazepine

Product 1

HCID 183874702-(2-Hydroxyethyl)-5-[4-(3,4-dichlorobenzoylamino)benzene-sulfonyl]-1,5-benzothiazepine

Procedure

Compound 4 as prepared in Example 25 was treated as described in Example 26 with 3,4-dichlorobenzoyl chloride (0.085 g, 0.41 mM) substituted for 2-phenylbenzoyl chloride to give the product. m/z (MH+)537

Workup

  1. additionwas treated
  2. customto give the product

Sources & evidence

ORD record
ord-ef539328838a43a8bcafe86911299cac
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

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