Hydrochloric Acid → HCID 178515343, compound

HRID 229676Notes

Reaction equation

HRID 229676 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:10](=[O:27])[N:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:14]=2)[N:4]=1.Cl>>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:10](=[O:27])[N:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:14]=2)[N:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 22318952HCID 22318952, compound

Product 1

HCID 178515343HCID 178515343, compound

Procedure

20 mg of 3-(2-methoxypyridin-6-yl)-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one is added to 3 ml of 5N hydrochloric acid. The mixture was heated under reflux for 3 hours, to which 0.5 ml of concentrated hydrochloric acid was added, and further stirred for 1 hour. The reaction mixture was concentrated under a vacuum and washed with ether, to quantitatively obtain the subject compound.

Workup

  1. temperatureThe mixture was heated
  2. additionwas added
  3. concentrationThe reaction mixture was concentrated under a vacuum
  4. washwashed with ether
  5. customto quantitatively obtain the subject compound

Sources & evidence

ORD record
ord-bf71d84458e7446ea2c9cb8535308eb9
Source dataset
uspto-grants-2009_07
Patent number
US07563811B2

Reaction notes

Loading…