HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 2-(2-Methanesulfonylethyl)-5-[(4-(2-phenylbenzoylamino)-benzenesulfonyl)]-1,5-benzothiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-(2-Hydroxyethyl)-5-[4-(2-phenylbenzoylamino)-benzenesulfonyl]-1,5-benzothiazepine | HCID 18387449 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-(2-Methanesulfonylethyl)-5-[(4-(2-phenylbenzoylamino)-benzenesulfonyl)]-1,5-benzothiazepine | HCID 70154856 | — |
Reaction Steps
Methanesulfonyl chloride (0.02 ml, 0.278 mM) was added to Compound 19 as prepared in Example 26 (0.151 g, 0.278 mM) and triethylamine (0.07 ml, 0.55 mM) following the procedure described in Example 29 to give the solid product. m/z (MH+) 623.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489321B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-3012d0d008a04819971118f3372ee1a9 |
| Source note | uspto-grants-2002_12 |