Methanesulfonyl chloride → 2-(2-Methanesulfonylethyl)-5-[(4-(2-phenylbenzoylamino)-benzenesulfonyl)]-1,5-benzothiazepine

HRID 2296763Notes

Reaction equation

HRID 2296763 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].O[CH2:7][CH2:8][CH:9]1[CH:15]=[CH:14][N:13]([S:16]([C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:39])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:12]2[CH:40]=[CH:41][CH:42]=[CH:43][C:11]=2[S:10]1>C(N(CC)CC)C>[CH3:1][S:2]([CH2:7][CH2:8][CH:9]1[CH:15]=[CH:14][N:13]([S:16]([C:19]2[CH:20]=[CH:21][C:22]([NH:25][C:26](=[O:39])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[CH:23][CH:24]=2)(=[O:18])=[O:17])[C:12]2[CH:40]=[CH:41][CH:42]=[CH:43][C:11]=2[S:10]1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 183874492-(2-Hydroxyethyl)-5-[4-(2-phenylbenzoylamino)-benzenesulfonyl]-1,5-benzothiazepine

Product 1

HCID 701548562-(2-Methanesulfonylethyl)-5-[(4-(2-phenylbenzoylamino)-benzenesulfonyl)]-1,5-benzothiazepine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Methanesulfonyl chloride (0.02 ml, 0.278 mM) was added to Compound 19 as prepared in Example 26 (0.151 g, 0.278 mM) and triethylamine (0.07 ml, 0.55 mM) following the procedure described in Example 29 to give the solid product. m/z (MH+) 623.

Workup

  1. customto give the solid product

Sources & evidence

ORD record
ord-3012d0d008a04819971118f3372ee1a9
Source dataset
uspto-grants-2002_12
Patent number
US06489321B1

Reaction notes

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