HRID2296763

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31297

Methanesulfonyl chloride

CH3ClO2S

结构：O=C(Nc1ccc(S(=O)(=O)N2C=CC(CCO)Sc3ccccc32)cc1)c1ccccc1-c1ccccc1

HCID18387449

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)CCC1C=CN(S(=O)(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1

HCID70154856

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Methanesulfonyl chloride (0.02 ml, 0.278 mM) was added to Compound 19 as prepared in Example 26 (0.151 g, 0.278 mM) and triethylamine (0.07 ml, 0.55 mM) following the procedure described in Example 29 to give the solid product. m/z (MH+) 623.

WORKUP

后处理

customto give the solid product

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3012d0d008a04819971118f3372ee1a9
来源数据集: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06489321B1
来源说明: uspto-grants-2002_12

反应 SMILES

[CH3:1][S:2](Cl)(=[O:4])=[O:3].O[CH2:7][CH2:8][CH:9]1[CH:15]=[CH:14][N:13]([S:16]([C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:39])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:12]2[CH:40]=[CH:41][CH:42]=[CH:43][C:11]=2[S:10]1>C(N(CC)CC)C>[CH3:1][S:2]([CH2:7][CH2:8][CH:9]1[CH:15]=[CH:14][N:13]([S:16]([C:19]2[CH:20]=[CH:21][C:22]([NH:25][C:26](=[O:39])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[CH:23][CH:24]=2)(=[O:18])=[O:17])[C:12]2[CH:40]=[CH:41][CH:42]=[CH:43][C:11]=2[S:10]1)(=[O:4])=[O:3]