Hydrochloric Acid → HCID 22997337, compound

HRID 2296897Notes

Reaction equation

HRID 2296897 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:71]=[CH:70][C:13]([CH2:14][NH:15][C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]([C:36]4[CH:41]=[CH:40][C:39]([O:42][C:43]([N:45]5[CH2:50][CH2:49][N:48]([C:51](=[O:69])[NH:52][CH2:53][C:54]6[CH:59]=[CH:58][C:57]([CH2:60][NH:61]C(OC(C)(C)C)=O)=[CH:56][CH:55]=6)[CH2:47][CH2:46]5)=[O:44])=[CH:38][CH:37]=4)([CH3:35])[CH3:34])=[CH:29][CH:28]=3)=[O:25])[CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1)=O)(C)(C)C.[ClH:72]>O1CCOCC1>[ClH:72].[ClH:72].[NH2:8][CH2:9][C:10]1[CH:71]=[CH:70][C:13]([CH2:14][NH:15][C:16]([N:18]2[CH2:19][CH2:20][N:21]([C:24]([O:26][C:27]3[CH:28]=[CH:29][C:30]([C:33]([C:36]4[CH:41]=[CH:40][C:39]([O:42][C:43]([N:45]5[CH2:46][CH2:47][N:48]([C:51](=[O:69])[NH:52][CH2:53][C:54]6[CH:55]=[CH:56][C:57]([CH2:60][NH2:61])=[CH:58][CH:59]=6)[CH2:49][CH2:50]5)=[O:44])=[CH:38][CH:37]=4)([CH3:35])[CH3:34])=[CH:31][CH:32]=3)=[O:25])[CH2:22][CH2:23]2)=[O:17])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86758627HCID 86758627, compound

Product 1

HCID 22997337HCID 22997337, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.14 g of 2,2-bis-{4-[4-(4-tert-butoxycarbonylaminomethylbenzylcarbamoyl)-1-piperazinylcarbonyloxy]-phenyl}propane is dissolved in 2 ml of abs. dioxane, and 2 ml of an approx. 20% solution of hydrogen chloride in dioxane is added to this solution. The mixture is stirred overnight and the precipitate is filtered off with suction, washed twice with diethyl ether and dried in vacuo. 0.08 g of the title compound, having a m.p. of from 250° C. (decomposition), is obtained.

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. washwashed twice with diethyl ether
  3. customdried in vacuo
  4. customis obtained

Sources & evidence

ORD record
ord-035823da9b744789810d6c152909abdf
Source dataset
uspto-grants-2002_12
Patent number
US06489327B1

Reaction notes

Loading…