Hydrochloric Acid → HCID 22997343, compound

HRID 2296898Notes

Reaction equation

HRID 2296898 reaction equation
[ClH:1].Cl.C(OC([N:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([C:28]3[CH:33]=[CH:32][C:31]([O:34][C:35]([N:37]4[CH2:42][CH2:41][N:40](C(OC(C)(C)C)=O)[CH2:39][CH2:38]4)=[O:36])=[CH:30][CH:29]=3)([CH3:27])[CH3:26])=[CH:21][CH:20]=2)=[O:17])[CH2:12][CH2:11]1)=O)(C)(C)C.Cl>O1CCOCC1.C1(C)C=CC=CC=1>[ClH:1].[ClH:1].[N:13]1([C:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([C:28]3[CH:29]=[CH:30][C:31]([O:34][C:35]([N:37]4[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]4)=[O:36])=[CH:32][CH:33]=3)([CH3:27])[CH3:26])=[CH:21][CH:20]=2)=[O:17])[CH2:12][CH2:11][NH:10][CH2:15][CH2:14]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22997358HCID 22997358, compound

Product 1

HCID 22997343HCID 22997343, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 312751,4-DioxaneSolvent2×

Procedure

8.3 g of 2,2-bis[4-(4-tert-butoxycarbonyl-1-piperazinylcarbonyloxy)phenyl]propane dihydrochloride are dissolved in 50 ml of abs. dioxane, and 9.5 ml of an approx. 20% solution of hydrogen chloride in dioxane are added to this solution while stirring. The mixture is stirred overnight, after which it is diluted with toluene and the precipitate is filtered off with suction. After drying in vacuo, 5.7 g of the title compound, having a m.p. of from 200° C. (decomposition), are obtained.

Workup

  1. stirringThe mixture is stirred overnight
  2. filtrationthe precipitate is filtered off with suction
  3. dry with materialAfter drying in vacuo, 5.7 g of the title compound
  4. customare obtained

Sources & evidence

ORD record
ord-836a3ce854bb42cbbe1f216844b51407
Source dataset
uspto-grants-2002_12
Patent number
US06489327B1

Reaction notes

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