Sodium hydride → HCID 53712208, compound

HRID 2297006Notes

Reaction equation

HRID 2297006 reaction equation
O[CH2:2][P:3](=[O:10])([O:7][CH2:8][CH3:9])[O:4][CH2:5][CH3:6].[H-].[Na+].Br[CH2:14][C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[C:17](C)[N:16]=1>C1(C)C=CC=CC=1>[CH2:5]([O:4][P:3]([CH2:2][C:17]1[CH:18]=[C:19]([CH3:21])[CH:20]=[C:15]([CH3:14])[N:16]=1)([O:7][CH2:8][CH3:9])=[O:10])[CH3:6]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 76513Diethyl phosphonomethanolHCID 222804052-(Bromomethyl)-4,6-dimethylpyridine

Product 1

HCID 53712208HCID 53712208, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of diethyl hydroxymethylphosphonate (1 mmole) in toluene was treated with sodium hydride (1.1 mmole) at 0° C., and after 15 min 2-bromomethyl-4,6-dimethylpyridine (1 mmole) was added. After 3 h the reaction mixture was subjected to extraction and chromatography to give 2-diethylphosphonomethyl-4,6-dimethylpyridine.

Workup

  1. extractionAfter 3 h the reaction mixture was subjected to extraction and chromatography

Sources & evidence

ORD record
ord-a326350248a941fa988ca88f656dbc16
Source dataset
uspto-grants-2002_12
Patent number
US06489476B1

Reaction notes

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