Hydrochloric Acid → HCID 22280564, compound

HRID 2297020Notes

Reaction equation

HRID 2297020 reaction equation
[Si]([O:18][CH2:19][CH2:20][C:21]([F:32])([F:31])[CH2:22][P:23](=[O:30])([O:27][CH2:28][CH3:29])[O:24][CH2:25][CH3:26])(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.Cl>CO>[OH:18][CH2:19][CH2:20][C:21]([F:32])([F:31])[CH2:22][P:23](=[O:30])([O:24][CH2:25][CH3:26])[O:27][CH2:28][CH3:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22280667HCID 22280667, compound

Product 1

HCID 22280564HCID 22280564, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of diethyl 4-(tert-butyldiphenylsilyloxy)-2,2-difluorobutylphosphonate (1 mmole) in methanol (1 mL) was treated with hydrochloric acid (4 N, 4 mmole) at 0° C., and the resulting reaction was stirred at room temperature for 2 h. Evaporation and chromatography gave diethyl 4-hydroxy-2,2-difluorobutylphosphonate as a clear oil.

Workup

  1. customthe resulting reaction
  2. customEvaporation and chromatography

Sources & evidence

ORD record
ord-48f1d0261ab047f0be1e455f11a100bd
Source dataset
uspto-grants-2002_12
Patent number
US06489476B1

Reaction notes

Loading…