4-Methoxy-2-aminobenzothiazole → 2-Amino-4-hydroxybenzothiazole

HRID 2297024Notes

Reaction equation

HRID 2297024 reaction equation
[Al+3].[Cl-].[Cl-].[Cl-].[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15]C)[C:9]=2[N:10]=1>CCS>[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[C:9]=2[N:10]=1

Participants

4

Reactant 2

HCID 216224-Methoxy-2-aminobenzothiazoleHCID 6451240Aluminum(III) Chloride

Product 1

HCID 240572-Amino-4-hydroxybenzothiazole

Reagents, catalysts & solvents 1

HCID 6343EthanethiolSolvent

Conditions

Temperature
2.5 °C

Procedure

A solution of AlCl3 (5 mmole) in EtSH (10 mL) was cooled to 0° C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole). The mixture was stirred at 0-5° C. for 2 h. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

Workup

  1. customEvaporation and extraction

Sources & evidence

ORD record
ord-19fed726a11443f3972e553b933a70a5
Source dataset
uspto-grants-2002_12
Patent number
US06489476B1

Reaction notes

Loading…